Most of the newer North American highways are built to superior standards, but it often means traffic travels so much faster, sometimes negating the feeling of security that a wide shoulder provides. It seems Europeans expect more bikes to be on the minor roads than Americans do, and the drivers react accordingly. Too many American drivers tend step on the gas wanting to pass a cyclist as fast as possible.
Europe has more established bike routes, but I'm impressed with the recent developments in the US this past decade.
Accommodation-wise, it really depends on the kind of lodging you are looking for. Europe has far more cheap hostels, and most of their campgrounds have a fee structure that's kinder to cyclists as they charge by the motor vehicle, tent and per person separately. America has a lot more stealth camping opportunities, and cheap motels. It is easier to find a cheap hotel in the downtown of a large European city like Paris or Berlin than say in Boston, New York or Chicago where you have to settle with the outskirts.
The variety of food on the road is getting better in America, but there's definitely more vernacular in Europe with its genuinely rich regional cuisines.