If clearance allows, nylock nuts beat loctite by a long shot.
I'm curious why you think so. The only advantage of nylock nuts I can think of is the ease of installation.
For a bike used at home, it makes no difference since I always have Loctite available. Out on tour, Loctite is just one more piece of gear I leave behind so the security of the nylock nut is peace of mind... especially while flying as disassembly and reassembly of racks and fenders becomes necessary.