For instance, if my shifting isn't crisp and quick, I'll adjust it when I'm commuting or riding around home. On tour, I'll allow a bit more slop -- as long as I can downshift, it's OK if it takes a second to shift up.
Conversely, I can deal with a wheel a bit out of true near home (especially after a winter of commuting). On tour, I know I risk high speed shimmy if the wheel's out, so that gets addressed immediately (or as soon as I get to the bottom of the hill).
How do you all deal with little imperfections?