This question is really for the women out there, but I would appreciate the man's perspective too.
Mostly from a man's perspective: I've got a B-17 on each of my bikes. Putting a seat cover on to keep the saddle from getting soaked is worth it to me for the ride. Get it adjusted right (two-bolt seatposts are wonderful things) and you'll never look back.
From a woman's perspective, my daughter stole the sprung Brooks Champion I was going to ride on our TransAm two months before we left. She still does overnight/weekend tours on it, four years later. I re-tightened her saddle once on the TransAm, and I think she may have tightened it once or twice since then. I haven't got that saddle back.