Another source for information is the US Bicycle Route System page on our site. There are pdfs and links to a lot of different articles that could be helpful to you.
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A widening of US 1 past the Last Chance Saloon might let you cut some miles off your trip by passing up Card Sound Road, but check it out for sure first.
Thank you everyone so much for the advice! Since I originally posted this thread, some new questions have come to mind. Does anyone have a recommendation for a good bike lock and were you ever in a situation where you didn't have an ideal spot to lock your bike? How did you deal with washing your clothes each day/dealing with them being damp for awhile? And also I'm trying to carry as little weight as possible...if anyone has a recommendation for a very light weight easily packable tent, I plan to buy one soon. I also am thinking of how I will go about packing for this trip. I don't want to use a trailer. The only things I figure I'll be carrying are toiletries, a tent, and water/snacks plus spare tires and general necessities. Should I use panniers or what do you guys think the best way for me to go about packing my bike is with the goal of being as light as possible? Thanks again for the help!
The TransAm to Western Express looks great to me because it ends right in San Fransisco. I would probably have to ride up to Damascus, VA or Berea, KY to hop on the TransAm. The Western Express + TransAm East package looks like it will cover most me most of the time. Are there maps that would cover my route from SC to KY or VA? If not are there any ideas on how to plan that on my own?