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I guess it depends on what exactly is meant by "broken in". I found it pretty comfortable right out of the box, but then it seems to get more comfortable as time goes by. When does the breaking in stop and the breaking down start? Hard to say, but I would say that my saddle got progressively more comfortable throughout the first 4000 miles.
For me without a doubt is the Sella Anatomica Titanico. I have tried at least 9 different saddles over the years. Last September I did a short 200 mile tour using the Sella saddle for the first time. Never once did I experience pain or discomfort. As well I did not use any sort of cream.