I would think you could do a lot of the US riding from hotel to hotel. I just don't think you could do everything that way.
In 2000, I did part of the continental divide route in New Mexico. We carried 14 lliters of water each, as we did not think we could resupply everyday. We went three days without resupply, because there was nothing. A lot of the streams on the map were dry ravines. On the 3rd day, we stopped at ranch and asked for water and were chased off by the owner. We found water later on that day at a ranger station.
So it all depends on your route.