Comment: When I did the Transamerica going East to West I arrived at Washington Dulles and started biking. All the hassle with domestic flights, rental cars, greyhound, amtrak etc is just too complicated.
PS: I am from Denmark, Europe.
PPS: As far as I know people usually dont have jetlag going from Europe to USA ... only the other way around. I for instance started biking right away and did not need time to adjust.