Will the Americano, with 700x38c cross tires handle my 220 lbs plus overnight camping gear on that kind of terrain. The Canal will be my main testing ground for preparing to do the TransAm.
In dry weather, the Americano will be fine with those tires. You may bog down a little on chat when raining if the water is standing. On the road, you will have no trouble. Think a little more long-term regarding where you will be riding. Is it mostly on the C&O/gravel roads/etc. or on pavement. Buy accordingly. Congrats on your excellent bike, whichever you choose!