Pennsylvania DOT has signed bike routes
that are quite useful. In general these routes avoid busy highways and the signage, at least for Route S, is complete. This summer I followed Route S across PA from just north of Philadelphia and took the GAP up to Pittsburgh. After that I joined the Northern tier heading west. You will want to stay further south I presume. Route S is nice riding.
There were a couple of places I was scratching my head as to where the route went but I managed to resolve the issue with a bit of riding back and forth. I once asked two State Patrol officers where Route S went. They had no idea what I was talking about! After about Gettysburg (slightly off route) the hills start in earnest and get steeper and more frequent as you head west. But don't let that put you off. It's no worse than Tuscany.
BTW Philadelphia has a huge Italian community I believe