The BF is somewhat easier to pack and a unpack, fits into a smaller case and is easier to transport through airports, etc. It is "different" to ride as the small wheels have their own characteristics. You do get used to it but it's noticably different from a full size wheel bike.
The Co-Motion (and the Bilenky) are perfectly "normal" bikes that happen to disassemble for travel. Once put together, the couplers are completely transparent to the rider and every thing about the bike is conventional. Packing and unpacking take a bit longer than the BF and the packed bike is in a significantly larger case that can be a bit awkward to handle.
Trade offs: The Bike Friday is easier to travel with. The Co-Motion is better to ride.