Sent from somewhere around here.
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IMHO West to East will be easier if you are low on conditioning. East to West has more steeper climbs early on.I found that to be true. In fact I found the Appalachians to be the hardest part and the climbs out of the river valleys in the Ozarks were a challenge as well.
But I believe you will hook up and share the experience with more riders going east-west. This is from reading several journals and my experience as well.I didn't notice that, but I have only done it W-E. Not sure why that would be the case. I am curious, care to elaborate?