I agree with Staehpj1. In over 30 years of touring, the only negative interactions I have experienced have been with motorists driving by, you know, the finger, the yell, etc. With people I actually meet, it's all been positive, even to the point of going up to the cash register to pay the bill for breakfast and being told it was already taken care of buy an anonymous person in the cafe.
A little off topic, but one of the strangest things I've noticed about the people I meet is that locals often know nothing about local geography, roads, etc. They can't tell you which road to take, where a particlar road goes, etc, even when I'm asking in a small town where a road leaving is going or which way to another nearby town or how far it is or especially if a road is hilly or not. I think I often leave a town I've never been to before knowing more about the area than the people living there!