I looked up information on that route. There is a book with detailed information for cycling the Mississippi river trail. In the northern part near and in Minnesota I remember it was extremely humid and hot. The mosquitoes came in thick swarms and carried men away. Read, "Life on the Mississippi" by Mark Twain for an appreciation of the history of the towns there, and the early settlements. The river has catfish six feet long that have been known to jump ashore and swallow small dogs whole. There are snapping turtles that weigh in at 200 pounds, just in case you need to take a swim to simmer down after a day on the road. While resting at the water's edge one afternoon I saw a large garfish jump ten feet out of the water and snatch a bird off a limb of a tree. In some northern parts there are many short, abrupt, steep hills. That's on the west side of the river. Another road a bit farther to the west of the river is less hilly.