Hi, Sean: I've ridden part of the route you are interested. My wife and I rode a desert section, Victorville to just past Amboy in the Mojave desert. This was in the winter. This was some wonderful riding with one exception: The strip from just east of Newberry Springs to Ludlow has perhaps the worst pavement on the planet if not the solar system: ridges, cracks, cobbles, unspeakably horrible. My suggestion is to ride just a bit east of Newberry Springs (you've got to see the Bagdad Cafe!) then get on to the main highway for the bit down to Ludlow. The shoulder is huge and you'll have a nice quick, sometimes downhill run. Beyond Ludlow, you'll have a little bit of the rough stuff, but the road improves quickly. We turned north on the Kelbaker road just past Amboy, so I can't speak to the road beyond that. I've heard the stretch through Oatman and beyond into Arizona is quite nice. Timing will be important as this desert section can be incredibly hot.
Best of luck!