I am forwarding this information from phred.org Touring group. Go there to get Jamie's original posting. Hope it helps Joan.
Owen Sound is one of the larger "near north" cities and as a hub city,
> it has all of the services you'd expect of a city 4 times it's size.
> It no longer has passenger rail service, but does have Greyhound bus
> service. There are also car rental places (as you'd expect) but
> one-way rentals on cars are expensive. (http://www.owensound.ca
> There is a regularly scheduled run from Owen Sound to Buffalo via
> Greyhound. There are also more frequent Owen Sound to Toronto and
> Toronto to Buffalo runs.
> The part of Ontario you'll be in is actually the most densely
> populated part of Canada and the bus service matches that.
> You may find it easier (based on schedules) to go Owen Sound ->
> Toronto -> Niagara Falls Canada and then ride across to the states --
> Niagara to Buffalo isn't that far and you can get in a couple of
> additional stops for sightseeing.
> (Of course, all the caveats of travelling by Greyhound apply.)
> There is another carrier that does the Guelph - Buffalo portion of the
> route you're taking called Coach Canada
) -- they take bikes
> underneath the bus and ask only that you bag them (bag cost is $10 at
> the terminal). Owen Sound to Guelph is a fairly easy ride (yes it's
> over a set of glacial drumlins, but the elevations trends down (: )
> Of note, the Bruce Trail parallels most of your route, and there are
> many services for those who are thru-hiking it.
> You'll have a lot of fun - I grew up going back and forth from Guelph
> to Owen Sound / Sauble Beach - there's lots to see and do.