I have thousands of miles with all three Schwalbe tires
37-622 XR - No flats, not great traction on wet pavement, sidewall failure after 7500 miles
37-622 Supreme - Smooth riding, great traction, tread delamination after 4000 miles, one puncture every 500 miles
30-622 Racers - Fast accelerating, no flats for 2000 miles (so far, still running these unloaded)
I bought into the Supremes buzz when they came out and was disappointed by their susceptibility to puncture and their durability compared to the XR. Unfortunately Schwalbe is discontinuing the XR, replacing it with three: Durene, Extreme, Supreme. They leave it to you to pick the one that replaces the XR.
Schwalbe seems to be pushing the Marathon Plus Tour for puncture resistance and durability, but it weighs 890g in the 37-622 . There is no way I'd run a tire that heavy. The XR was heavy enough!