There are plenty of strategies, but regardless, your fanny must get conditioned for the seat, and that takes a little time. I have no problem at all most of the year, but the ol' undercarriage can't take much at the end of the winter when I have been riding very little for the previous three months. After a month or two of stepping up my mileage, I'm completely comfortable all day on the saddle again, even though the one on the bike I ride most now is one of the narrowest, hardest, lightest, and cheapest saddles I've ever used.
Oh, BTW, do make sure you're wearing cycling shorts, and don't wear underwear with them, since that defeats part of the purpose of cycling shorts, which is to avoid sitting on seams and wrinkles. Next, on the pad in the shorts, put a lot of vaseline, bag balm, or one of the products made for the purpose.