Check out the new route from SE Indiana into Kentucky via Ohio using the Historical Anderson Ferry. The route is for the most part on remote roads with the exception of US50 for a few miles in Ohio. I try to keep the routes off of highways as much as possible however doing so on this route adds miles and elevation. Crossing from Ohio into Kentucky the route uses the historic Anderson Ferry West of Cincinnati. Further down the road SW of Burlington Kentucky there is an option of riding through Rabbit Hash along the Ohio River. It's both scenic and nostalgic. Camping is available at Big Bone Lick State Park and motels just off the route near Walton.
My blog with lots of routes in Indiana: http://backroadsofindiana.blogspot.com/
"Back Roads of Indiana"