US 6 used to go all the way to L.A. Now it is truncated at Bishop, Calif.
Riding thru Vegas is tough - tougher recently that I-15 had major washout damage.
If you choose to go via US 6 - stay on the Western Express to Ely.
Then take US 6 via Tonopah to Bishop - - even more remote than US 50.
Then follow US 395 and/or side roads to Hwy 14 - runs along the eastern escarpment of the Sierras.
Hwy 14 has some expressway section with parallel service roads.
Then Soledad Pass Road to Santa Clarita.
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Or you can turn south at Tonopah and ride thru Death Valley - still hot.
Reconnecting to US 395 and Hwy 14.
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Or if you are in a hurry -
From Cortez, Colo - head west on McElmo Road to Bluff, Utah.
Then take US 163 thru Monument Valley - tough but very scenic.
Then US 160 to Tuba City and US 89 / Hwy 64 to Grand Canyon.
Continue on Hwy 64 to Williams - then you have to ride I-40 a few miles.
Get on to Old Route 66 thru Peach Springs to Kingman -
Then take Old Route 66 over the pass to Oatman and Needles.
Another short stretch of I-40 - then Old Route 66 via Amboy to Barstow.
These are the best preserved stretches of Old Route 66 - lots of roadside history.
BUT, BUT - - you need to be aware of temperatures and water in the Amboy stretch.
The Amboy Café is kinda reopened - you should be able to get water, but check first.