Having cycled about 39,000 miles through 19 countries and read the comments here, I agree that cycling a given interstate highway would in most all extents be safer than many of the alternative roads I have seen. I-10 going west from Texas through to I-8 into CA can be uncomfortable because of the trash, ruts and bumps and debris. Sure there is noise and pollution. Ear plugs solve one problem. Often winds will send the exhaust fumes in another direction. And away from the cities, the pollution is not all that bad. The fact there are two or three lanes going in one direction, and a median, and a side lane from 5 to six feet and sometimes wider makes it highly unlikely that someone will just happen to drift off the road precisely at your pinpoint location on straight ways. Complete care and caution would be required at entrances and exits. Like most any subject, if you examine it thoroughly, you will find it has positive and negative values. The questions here are these. Would allowing cyclists on all interstate highways be such a great move in advancing cycling safety? Would the positive outcomes so greatly outweigh the perceived negatives that to continue the prohibition would constitute some kind of harmful negligence? I have cycled interstates very much. IMO they are safer, noisier, and so rough and strewn with garbage in some lengths that an alternate route would be a better choice anyway. Some interstates are smooth going.