90 out of Jacksonville is your best bet. You can drop down to 20 for a faster ride. 90 is ok through AL and Miss. 90 seems to be the only way into New Orleans unless you go west and then south. I took 20 across the panhandle and 90 from AL to east of the Big Sleazy where I got 190 to Slidell, the TammanyTrace to Covington, and 190 through Baton Rouge. Beaumont, TX, Houston, San Antonio, Junction, TX, Roosevelt, TX, Kent, Van Horn, El Paso, Las Cruces, Deming, Lordsburg, Tucson, Yuma, Ocotillo, Jacumba, Pine Valley, Alpine, San Diego. Interstates 10 and 8 and hysterical highway 80. It was a blast. I like 20 more than 90. 90 has a lot more history to it in Florida. Perhaps many people are unaware that the largest single massacre of Indians did not happen in the western states, but in Florida. In a civil war battle in north Florida the confederates murdered a large number of black, wounded, surrendered, union, prisoners of war. Jackson County was the site of lynchings of negroes and the beating and torturing of children for a long time. Not that you need to know that to cycle there. One of Florida's governors implemented the mobile electric chair which sort of cooked people to death. An extremely sordid history. "Finding Florida" is recommended for anyone interested in the history of Florida. Reading only the received histories in text books will never tell you the truth.