I, too, use and recommend Ortliebs. I've been using one pair for a dozen years for commuting, with a cross-country trip and a few apple orchard runs every fall for good measure, with virtually no problems.
Moisture in the bags? Only happens when you put something wet in there. OK, sometimes you'll put wet clothes in a pannier on a damp morning; make sure your electronics go on the dry side (with sleeping bag?) those days, and dry everything including pannier insides out when you can.
Top loading problems? For comparison, in my backpacking days I carried a Kelty with top and bottom compartments, which was about the volume of both my Ortlieb Bikepackers together. I occasionally had problems finding something, usually because I couldn't remember if it was in the top or bottom of the backpack. Likewise, I'll occasionally have problems remembering if something is in the left or right pannier; however, digging the missing pair of gloves out is rarely a problem for me.
Now for the disclaimer. I bought Ortliebs Sportspacker plus after my old commuting Trek pannier attachment system wore out. I've never looked back. I bought another set for the back and a bar bag, but since I bought the first pair of Ortliebs I've never used anything else. Therefore, you might consider I'm one of those people who don't know what else is available since I found something I like, and I want more people to buy what I bought. That's true to some extent, though it's more because of the benefit I've gotten than my needing personal validation for my choices -- I don't care what other people buy or use.