I did that route a couple of years ago on my Kona Sutra touring bike (700 x 32 tires) with about 32 lbs of gear. I debated whether taking it at all since I'd heard it was tough. Ended up doing it and it's one of the best mistakes I ever made. All told, the first thing I'd say is that's it's incredibly beautiful, especially the portion where it parallels the coast. Second thing I'd say is that the hills are absolute killers, with some incredibly steep grades. Truth be told, I did get off and actually walk my bike up on several occasions but I made it. One other thing, the traffic was very light, almost non-existent. It's well worth it in my opinion. Another thing, water can be a bit hard to come by so make sure you have plenty. I ran out and had to "borrow" some from the outdoor faucet of an unattended home. Some nice little towns in route and a couple of good campgrounds. The hosts I dealt with were incredibly friendly. One even refused to charge me for camping saying I'd earned it by riding the hills. Bear in mind that I had extremely nice weather for my ride. I reckon it can be real nasty if the weather goes south. But, overall I would highly recommend it. It's great but it ain't easy. I'd say go for it, depending, of course, on the weather.