Kuralt's emotionalism lamenting the demise of small towns bypassed by interstate highways has its place in American nostalgia. Considering the tangible realities of the matter places it opposite of fact. Consider interstate 10. I have bicycled it a few times between Florida and California. Highway 90 west out of Beaumont runs near it. Many small towns are there to see and visit along the way. The I-10 service roads and 90 and other roadways can be cycled all the way from Huston to San Antonio. There are many towns along the way. I-10 going northwest out of San Antonio, TX goes through many small towns. There are hills and mountains and broad vistas, and very wide shoulders in many or most stretches. The climbs are gentler because the road cuts through the hills and does not go over their tops. Look at the map. You will see many interesting small towns along the way. I-10 also takes you to larger cities--- Houston, San Antonio, El Paso, Las Cruces, Tucson. I-8 going west from Casa Grande, AZ has wide shoulders and excellent scenery. You must exit 8 approaching Yuma, AZ.
Going due west from Yuma, unfortunately, puts you on the highway from hell. It is terrible for quite a distance. I did not measure its decrepitude but whatever its distance, it is too far. It smooths out and runs you alongside I-8 to Ogilvy or Ogilby Road. It takes you north to highway 78 where you again go west. Follow my route and you get to Ocotillo, CA. Before getting to Ocotillo there is a worse road from hell. And even along this route there are quite a few cool little towns and agricultural communities.
Going west from Ocotillo, I-8 is a long steep climb to where you must exit to hysterical highway 80. 80 is hilly and a bit rough in places. It is a super highway compared to the fore mentioned roads from hell. It runs along the I-8 corridor. On 80 you can visit a gambling casino. There is the town of Jacumba with hot springs if you can afford it. You will go through the very pleasant little town of Pine Valley. Here is a small restaurant of American nostalgia. I love looking at old photos from the past and memorabilia. Get ready to climb a bit. When you get to Alpine you can get an espresso at Starbucks if it is still there. It on the side of the road in plain sight. After a while you enter the megalopolis and thread your way into San Diego.
When Charles Kuralt said taking the interstate you will see nothing at all, it should be understood for what it was, an emotionalism.