Like I said, I've ridden it - - three times.
I have 100,000 miles of riding experience - bad habit.
Not sure about your experience level.
And that is important so that people can give you appropriate advice.
BC Hwy 16 is not a good route for an inexperienced rider.
Plus, it works a little better west-to-east -
So, the toughest section is last and downhill.
I've ridden up to Alaska/Yukon 6 times.
And you have to do northern BC to get there.
Or the Yellowhead out to Prince Rupert.
I just checked the traffic count data.
Hwy 16 west of PG has 11,000 AADT - that's a lot.
But the highway has been rebuilt with shoulders.
It drops to 8500, then 5500 getting into Vanderhoof.
Plus there are moderate shoulders.
The primary industry on the plateau is logging & lumber production.
You should expect logging trucks and adjust to them.
They are going fast on Hwy 16 - 80kmh/50mph.
The drivers are top-notch, courteous and experienced.
But their job is to get the logs to the mill.
From Vanderhoof to Burns Lake AADT drops further.
3500 down to 2500, but the shouder mostly disappears.
(Plus there are deep rumble strips .)
West of Burns Lake there is even less traffic -
With the exception of Houston, Smithers & Terrace.
Because of logging trucks, I'm not sure about best times to ride.
Summer traffic is heavier than winter - but March biking isn't pleasant.
Weekend traffic may include more RVs and boats,
but logging trucks are mostly a weekday operation when mills are running.
Some independents may run on Saturdays but nor many.
If the mill lot gates are locked, they can't drop off their loads.
Sunday mornings - almost everywhere - is the best time for low traffic.
Friday afternoons and Sunday afternoons are the worst for weekender traffic.
In general, mid morning to early afternoon avoids weekday rush hour traffic.
Even in rural areas, people commute to places like Prince George.
Towards in the morning, away in the evening.
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There are very few through roads the further north you go.
Hwy 16 is the most northerly east-to-west route in North America.
So there will be some traffic - a bit more than I usually like.
(And certainly more west of Prince George.)
As I said above, the towns and lakes on the plateau are very pleasant.
And as you head further west the scenery is outstanding.
(Provided you don't have lots of rain.)
Sadly, I have never had clear skies on the lower Skeena section.
My hope is that you do.
Pic - Logging Truck Turning onto Hwy 16