Hey Colleen,
You might check out WeatherSpark.com. It has a really good database of climate averages. Then you can decide what is best for you.
Couple of thoughts. While the wind may be overall WSW, the direction in the mountains can be quite localized due to the mountains forcing wind a certain direction so even if you are heading ENE, you could have a headwind. Certain open areas like Wyoming can have a strong preponderance of wind direction and that wind can be quite strong. I would not think the wind is that big of a factor overall as you will get wind from all directions regardless of the route's direction though if I had to guess, I would think the N>S would be SLIGHTLY favorable based on experience.
Another factor is are you an early riser or late riser. If early, N>S might be slightly better as the sun will be slightly less in your face.
Also, you don't say if you live at higher elevations currently. If you do not, you really should add a few days in Durango to acclimate (1 day per 1000 feet difference from the home elevation is recommended). If you go N>S, the wait can greatly be eliminated. However, if you go S>N, the temperature will be much more consistent than N>S.
Finally, be sure to check on the status of Jasper as it endured a major fire last summer. Certain services may not be available.
Hope you have a wonderful tour! Tailwinds, John