I live in Buffalo and helped develop the PPP route.
The US 16 route via Clearmont and Leiter is one of the most beautiful rides in the U.S.
Probably a bit better westbound with spectacular views of the approaching Bighorn Mountains.
But eastbound has lovely bluffs and ranches - plus low traffic and about 50% with shoulders.
Yes, I-90 allows bicycles and is about 30 miles shorter - but why? Why ride on an interstate?
For your purposes -
There is the Ucross Foundation at the junction of US 14 & US 16.
Just off the highway but not that far from Buffalo.
Lovely trees, excellent bathrooms, water, artists' shows.
https://www.ucrossfoundation.org/The Clearmont store is in the process of shutting down. Not sure of the exact date.
The couple who ran it were not able to sell it and plan to retire.
This is the case of small stores throughout rural America.
It is no longer possible to make a living with a mortgage and low sales.
(Often it is impossible even to get a loan.)
https://sheridanwyoming.com/2025/04/14/clear-creek-stop-closes-after-25-years-in-clearmont/The Leiter Bar & Cafe continues to improve and expand its services.
When the PPP was under development it was not a going concern.
They are very accommodating to cyclists and are aware how important their location is.
As a family-run business, they may be closed at times.
Contact them in advance to make sure they are open.
https://www.facebook.com/p/Leiter-Wy-Bar-Cafe-100055148364516/The Spotted Horse Bar is a bit funkier. They can be gruff with cyclists.
They have to truck in all their drinking water - so water isn't free.
They also have to do most their own shopping - no Sysco deliveries.
So there are times when they are closed - usually early in the week.
Contact them in advance to make sure they are open.
https://www.facebook.com/p/Spotted-Horse-Bar-and-Grill-100063743456003/Both Leiter and Spotted Horse depend on motorcyclists for much of their business.
The Harley crowd tends to drop more money - but cyclists should do their part, too.
That way we can get the Spotted Horse owners to be a little more chill with us.
Just before you reach Gillette is the Gillette/Campbell County Airport.
If you are parched or need to use the bathroom, you use the facilities.
It's only 5 miles north of Gillette.
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The Arvada Bar is about 3.5 miles off route, 8 miles east of Leiter.
There's not much savings since you have 7 miles of extra riding.
But the bar is about as Western as you can get and you can pitch a tent out back.
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The US 16 route from Buffalo to Gillette makes a big "U".
Northeast, then East, then almost due South.
Summer winds are prevailing southerly, often fairly strong.
(There are NO guarantees with wind direction or force.)
Winds are almost always lightest in the morning and strongest in late afternoon.
I suggest leaving Buffalo after lunch and catching the wind to Leiter.
The leaving Leiter as early as possible, so the stretch into Gillette isn't brutal.
In the latter case, Spotted Horse will probably be closed.
Pic - Red Hills along the route