I like 700c in the US and Europe and 26" in SA & SE Asia there are advantages to both. Here is the question. Fully loaded, how much more effort does it take to pedal a 26 inch wheel than a 700c wheel? How much speed do you lose? 2 or 3 mph over 3500 miles adds up.
With comparable tires, there should be no speed difference between either size. With the same tire, the 26" wheel will accelerate a little faster (spin up faster).
I will concede that the 26" wheel is a little more universally supported. If you ignore the availability of replacement tires, then I think it comes down to what kind of ground you need to cover. I am currently reading a blog about a couple doing a world tour. Currently they are in Mongolia, and conditions are so rough in Mongolia that if it were me, I would want to be riding a 26" wheel set. They are riding a 700Cs and actually blew out a Schwalbe XR tire. At the time, they thought they were stuck until they could ship in a new tire, but the local bike store (more of a market stall that a store) actually carried a 700C compatible tire. Apparently Chinese 28" rickshaw tires fit a 700C rim. I have no idea why you could buy Chinese 28" rickshaw tires.
I still have this notion that there are more road tires to choose from in the 700C size at US bike stores. Of course you can mail order Schwalbe's to fit almost any rim out there, including 27" rims.
I know of one person with S&S couplers. Yes his couplers came loose on a day ride, and yes he failed to check them before he rode. He decided that coupler were a pain. We have pretty much decided that if we can't drive the bikes there, we don't need to tour there. He did get a Bike Friday to take on business trips as it can be set up and torn down much easier than his S&S equipped Co-Motion Americano.
I remember visiting the S&S homepage in the last year. They make couplers that can be designed into any frame type, including carbon fiber. I think the only one you could retrofit was a steel frame since coupler is silver soldered on. I am pretty sure you cannot silver solder to aluminum, and I will confess that I have no idea what you can do with titanium. The S&S people were pretty adamant that you can retrofit any steel bike, and that the coupler will be stronger than the original tubing.